Table 1.

Comparison of traditional three-bag intravenous N-acetylcysteine (NAC) regimen with two-bag NAC regimens.

Traditional 3-bag FDA-approved regimen (“Prescott protocol”)	Bag 1 (administered over 15–60 minutes)	Bag 2 (administered over 4 hours)	Bag 3 (administered over 16 hours)
Dose	150 mg/kg in 200 mL D5W	50 mg/kg in 500 mL D5W	100 mg/kg NAC in 1,000 mL D5W
Simplified 2-bag, 20-hour regimen	Bag 1 (administered over 4 hours)		Bag 2 (administered over 16 hours)
Dose	200 mg/kg in 500 mL D5W		100 mg/kg in 1,000 mL D5W
SNAP* 12-hour IV NAC regimen	Bag 1 (administered over 2 hours)		Bag 2 (administered over 10 hours)
Dose	100 mg/kg in 200 mL D5W		200 mg/kg in 1,000 mL D5W

IV, intravenous; NAC, N-acetylcysteine; FDA, US Food and Drug Administration; mL, milliliter; D5W, dextrose 5% in sterile water; mg, milligram; kg, kilogram; SNAP, Scottish and Newcastle Antiemetic Pre-treatment for Paracetamol Poisoning, used in the United Kingdom with a unique treatment threshold (four-hour [APAP] = 100 mcg/mL nomogram line) compared to the United States (four-hour [APAP] = 150 mcg/mL nomogram line).