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Relationship between inflammatory response system (IRS)/CIRS and whole-brain white matter in SCZ and HCs. The average fractional anisotropy of SCZ was significantly lower than that of HCs (t = −5.44, P < .001) (A) and both groups were associated with IRS/CIRS in a negative trend, but not significant, taking age, sex, education, body mass index, and total intracranial volume as covariates. (B). SCZ, patients with schizophrenia; HCs, healthy controls. *** Significant at P < .001.
