Table 2.
Cytokine Levels and Different Types of Cytokine Profiles Expressed in Plasma of SCZ and HCs.
| SCZ(n = 120) Mean (SD) |
HCs(n = 65) Mean (SD) |
Statistics (F/t) |
P-value | |
|---|---|---|---|---|
| IRS | 1.44(8.36) | 0.00(7.40) | 1.16 | .248 |
| CIRS | −0.14(5.94) | 0.00(5.73) | −0.15 | .878 |
| IRS/CIRS | 1.57(4.42) | 0.00(3.55) | 2.64 | .009 |
| IFNγ (pg/ml) | 913.14(369.48) | 800.02(279.90) | 2.16 | .032 |
| IL1β (pg/ml) | 106.09(42.7) | 99.05(45.69) | 1.04 | .298 |
| IL2 (ng/ml) | 9.89(3.16) | 9.66(3.08) | 0.47 | .636 |
| IL6 (pg/ml) | 54.92(19.29) | 50.47(18.34) | 1.52 | .130 |
| IL8 (pg/ml) | 125.72(50.89) | 119.24(36.42) | 0.91 | .366 |
| IL12 (pg/ml) | 40.35(14.26) | 43.16(14.34) | −1.28 | .202 |
| IL17 (pg/ml) | 324.58(116.86) | 328.26(144.25) | −0.19 | .851 |
| IL18 (pg/ml) | 356.99(119.6) | 339.07(89.06) | 1.15 | .250 |
| TNFα(pg/ml) | 88.07(26.28) | 78.90(22.69) | 2.37 | .019 |
| IL1Ra (pg/ml) | 203.82(83.73) | 199.90(63.58) | 0.33 | .742 |
| IL4 (pg/ml) | 47.87(16.45) | 53.71(17.62) | −2.25 | .026 |
| IL10 (pg/ml) | 840.98(237.8) | 919.23(406.21) | −1.43 | .157 |
| sIL2Ra (pg/ml) | 404.26(121.38) | 390.01(107.34) | 0.79 | .429 |
| sIL2Rb (pg/ml) | 5173.98(1830.21) | 4925.39(2185.81) | 0.78 | .437 |
| TGFβ1(ng/ml) | 254.05(124.47) | 242.64(102.75) | 0.63 | .529 |
| TGFβ2(pg/ml) | 3605.00(1045.98) | 3645.87(1203.33) | −0.24 | .810 |
Note: SCZ, patients with schizophrenia; HCs, healthy controls. IRS, immune-inflammatory response system, computed as z composite score of IFNγ, IL1β, IL2, IL6, IL8, IL12, IL17, IL18, and TNFα.
CIRS, compensatory immune-regulatory system, computed as z composite score of IL1Ra, IL4, IL10, sIL2Ra, sIL2Rb, TGFβ1, and TGFβ2. IRS/CIRS, computed as z(IRS) – z(CIRS).
The bold font represents P < .05.