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Manhattan plots of MTAG-OUD (NEffective = 176 876), MTAG-CUD (NEffective = 223 956), MTAG-AUD (NEffective = 282 208) and MTAG-SMK (NEffective = 709 603). Dashed lines indicate genome-wide significance (P < 5 × 10−8) and yellow dots indicate genome-wide significance single nucleotide polymorphisms. AUD, alcohol use disorder; CUD, cannabis use disorder; OUD, opioid use disorder; MTAG, multi-trait analysis of genome-wide association studies; SMK, smoking.
