TABLE 1.

Summary of MTAG results.

	EUR								AFR
	OUD		CUD		AUD		SMK		OUD		AUD		SMK
	GWAS	MTAG	GWAS	MTAG	GWAS	MTAG	GWAS	MTAG	GWAS	MTAG	GWAS	MTAG	GWAS	MTAG
SNPs used for MTAG	2 888 846		2 888 846		2 888 846		2 888 846		2 648 505		2 648 505		2 648 505
SigSNPs	18	1465	7	2547	363	1854	3049	5380	3	7	59	45	0	3
SigSNPs (after clumping)	4	41	2	74	20	63	105	183	1	2	4	3	0	1
Independent locus	4	36	2	60	12	52	74	144	1	2	2	2	0	1
χ2	1.159	1.376	1.099	1.455	1.281	1.463	1.771	1.865	1.021	1.045	1.053	1.055	1.044	1.049
Effective sample size	74 635	176 876	48 900	223 956	171 601	282 208	632 802	709 603	32 240	68 047	67 686	71 092	40 736	45 743

Abbreviations: AFR, African ancestry; AUD, alcohol use disorder; CUD, cannabis use disorder; EUR, European ancestry; GWAS, genome-wide association studies; OUD, opioid use disorder; MTAG, multi-trait analysis of GWAS; SMK, smoking; SNPs, single nucleotide polymorphisms, SigSNPs, SNPs that reach a genome wide significant p-value threshold < 5 × 10⁻⁸.