TABLE 2.
PRS increment R2.
| GWAS-PRS | MTAG-PRS | ||
|---|---|---|---|
|
| |||
| Opioid | Ever used opioid | 0.97% | 2.31% |
| DSM-IV diagnosis | 1.03% | 2.26% | |
| DSM-5 diagnosis | 1.01% | 2.16% | |
| Cannabis | Ever used cannabis | 0.38% | 1.62% |
| DSM-IV diagnosis | 0.19% | 0.91% | |
| DSM-5 diagnosis | 0.23% | 1.13% | |
| Alcohol | Ever used alcohol | 0.26% | 1.11% |
| DSM-IV diagnosis | 0.91% | 1.68% | |
| DSM-5 diagnosis | 0.84% | 1.72% | |
| Smoking | Ever used smoking | 1.81% | 2.04% |
| DSM-IV diagnosis | 3.43% | 4.16% | |
Abbreviations: DSM, Diagnostic and Statistical Manual of Mental Disorders; GWAS, genome-wide association studies; MTAG, multi-trait analysis of GWAS; PRS, polygenic risk scores.