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. 2023 Oct 24;38(12):2433–2446. doi: 10.1093/humrep/dead214

Table 4.

Difference in quality of life domains between the dietary interventions and control group, compared longitudinally over the follow-up period of 6 months.

Intervention (FODMAP1 or endometriosis diet)
 Control
n = 43
 n = 19
Domains of quality of life measured using the EHP-302 Baseline EHP-30 score (median, IQR) Three-month EHP-30 score (median, IQR) Six-month EHP-30 score (median, IQR) Baseline EHP-30 score (median, IQR) Three-month EHP-30 score (median, IQR) Six-month EHP-30 score (median, IQR) Mean difference3 (95% CI) P-value
Pain 42.0 (29.0) 25.0 (39.2) 22.7 (37.5) 28.4 (33.5) 31.8 (13.6) 22.7 (25.0)

  • −2.41 (−8.97 to 4.15)

  • 0.469

Powerlessness 50.0 (30.2) 20.8 (29.2) 16.7 (29.2) 35.4 (31.3) 37.5 (12.5) 29.2 (25.0)

  • −4.31 (−10.86 to 2.24)

  • 0.195

Emotional wellbeing 33.3 (33.3) 25.0 (32.3) 20.8 (32.3) 31.3 (26.0) 37.5 (25.0) 16.7 (25.0)

  • −1.83 (−7.53 to 3.88)

  • 0.528

Social support 34.4 (39.1) 37.5 (43.8) 28.1 (31.3) 43.8 (39.1) 50.0 (31.3) 37.5 (18.8)

  • −11.26 (−18.77 to −3.74)

  • 0.004

Self-image 50.0 (43.8) 25.0 (41.7) 25.0 (39.6) 41.7 (27.1) 33.3 (33.3) 25.0 (58.3)

  • −1.45 (−9.59 to −6.69)

  • 0.726

Work life 25.00 (40.0) 7.50 (28.75) 5.0 (25.0) 10.00 (15.0) 15.0 (18.75) 10.0 (22.5)

  • 1.89 (−4.77 to 8.55)

  • 0.576

Children 0.0 (37.5) 0.0 (21.9) 0.0 (9.4) 0.0 (0.0) 0.0 (0.0) 0.0 (0.0)

  • 3.66 (−3.22 to 10.53)

  • 0.295

Sexual intercourse 45.0 (51.3) 25.0 (40.0) 27.5 (47.5) 50.0 (42.5) 50.0 (45.0) 15.0 (75.0)

  • −6.97 (−15.79 to 1.85)

  • 0.120

Medical profession 6.3 (37.5) 15.6 (31.3) 12.5 (37.5) 18.8 (37.5) 25.0 (56.3) 40.6 (39.1)

  • −17.96 (−30.26 to −5.66)

  • 0.005

Treatment 41.7 (39.6) 37.5 (33.3) 33.3 (41.7) 33.3 (25.0) 25.0 (45.8) 25.0 (66.7)

  • 7.17 (−2.21 to 16.55)

  • 0.132

Infertility 71.9 (32.8) 87.5 (–) 56.3 (56.3) 87.5 (31.3) 75.0 (25.0) 81.3 (–)

  • −9.37 (−25.60 to 6.86)

  • 0.243

Low-FODMAP diet
 Endometriosis diet
n = 22
 n = 21
Domains of quality of life measured using the EHP-30 Baseline EHP-30 score (median, IQR) Three-month EHP-30 score (median, IQR) Six-month EHP-30 score (median, IQR) Mean difference4 (95% CI) P-value Baseline EHP-30 score (median, IQR) Three-month EHP-30 score (median, IQR) Six-month EHP-30 score (median, IQR) Mean difference4 (95% CI) P-value
Pain 43.2 (28.4) 20.5 (34.1) 15.9 (31.8) −3.60 (−11.15 to 3.95) 0.348 40.9 (37.5) 29.5 (39.8) 22.7 (50.0)

  • −1.36 (−8.80 to 6.09)

  • 0.720

Powerlessness 54.2 (27.1) 20.8 (41.7) 16.7 (37.5) −1.38 (−8.90 to 6.14) 0.718 45.8 (43.8) 20.8 (27.1) 16.7 (35.4)

  • −6.80 (−14.20 to 0.61)

  • 0.072

Emotional wellbeing 37.5 (37.5) 25.0 (37.5) 20.8 (37.5) 0.81 (−5.72 to 7.34) 0.807 33.3 (33.3) 25.0 (20.8) 20.8 (27.1)

  • −4.15 (−10.58 to 2.28)

  • 0.204

Social support 31.3 (40.6) 43.8 (43.8) 31.3 (50.0) −6.93 (−15.48 to 1.62) 0.111 37.5 (40.6) 12.5 (46.9) 25.0 (34.4)

  • −15.47 (−23.89 to −7.06)

  • <0.001

Self-image 50.0 (50.0) 25.0 (41.7) 33.3 (58.3) 1.08 (−8.26 to 10.42) 0.820 50.0 (37.5) 33.3 (37.5) 16.7 (29.2)

  • −3.98 (−13.18 to 5.23)

  • 0.395

Work life 30.0 (40.0) 5.0 (20.0) 5.0 (25.0) 3.12 (−4.59 to 10.83) 0.425 22.5 (38.8) 10.0 (32.5) 5.0 (10.0)

  • 0.86 (−6.77 to 8.49)

  • 0.824

Children 0.0 (43.8) 0.0 (12.5) 0.0 (0.0) 4.40 (−3.52 to 12.32) 0.274 0.0 (37.5) 0.0 (25.0) 0.0 (18.8)

  • 2.99 (−4.80 to 10.78)

  • 0.450

Sexual intercourse 45.0 (50.0) 20.0 (40.0) 30.0 (50.0) −9.97 (−20.09 to 0.14) 0.053 45.0 (47.5) 30.0 (35.0) 20.0 (50.0)

  • −4.31 (−14.27 to 5.66)

  • 0.394

Medical profession 6.3 (37.5) 15.6 (53.1) 12.5 (18.8) −17.14 (−31.27 to −3.00) 0.018 0.0 (43.8) 12.5 (31.3) 6.3 (42.2)

  • −18.71 (−32.79 to −4.63)

  • 0.010

Treatment 25.0 (37.5) 33.3 (33.3) 41.7 (37.5) 5.35 (−5.12 to 15.82) 0.312 50.0 (25.0) 41.7 (41.7) 33.3 (25.0)

  • 9.33 (−1.35 to 20.01)

  • 0.086

Infertility 68.8 (–) 68.8 (–) 56.3 (–) −11.88 (−31.66 to 7.90) 0.224 78.1 (–) x 56.3 (56.3)

  • −6.08 (−26.87 to 14.70)

  • 0.550

Mean differences with interquartile ranges (IQRs) were calculated using mixed models.

Bold values indicate P-values.

1

FODMAP: fermentable oligo-, di-, mono-saccharides, and polyols.

2

EHP-30 Questionnaire: endometriosis health profile 30 questionnaire (range 0–100).

3

Difference calculated between baseline, 12- and 24-week follow-up, between the two dietary interventions and control group.

4

Difference calculated between baseline, 12- and 24-week follow-up. Difference calculated between the Low FODMAP diet and control group, and between endometriosis diet and control group.