Table 3.
Effects of vitamin D supplementation on thyroid autoantibody and thyroid function in patients with HT (T vs C).*
| Included trials | TPO-Ab (U/mL) | TG-Ab (U/mL) | TSH (mIU/L†) | FT4 | FT3 |
|---|---|---|---|---|---|
| Huang, 2013[51] | −208.81 ± 141.28 vs −84.51 ± 149.82 | −417.07 ± 452.69 vs −142.11 ± 375.4 | −87 ± 15 vs −76.4 ± 25.08 | 10.9 ± 2.72 vs 9.98 ± 2.87 pmol/L | 2.9 ± 1.04 vs 2.6 ± 1.01 pmol/L |
| Han et al, 2015[50] | −408.04 ± 61.46 vs −222.76 ± 66.39 | −55 ± 7.55 vs −31.3 ± 7.75 | −18.19 ± 7.05 vs −15.41 ± 6.48 µIU/L | 0.85 ± 0.23 vs 0.36 ± 0.28 ng/dL | 2.1 ± 0.69 vs 0.97 ± 0.79 pg/mL |
| Zhao et al, 2016[48] | −224 ± 115.05 vs −97 ± 119.53 | −270 ± 316.6 vs −178 ± 284.23 | −77.7 ± 12.91 vs −78.6 ± 11.67 | 9.8 ± 2.72 vs 9.5 ± 2.26 pmol/L | 2.2 ± 1.31 vs 1.8 ± 0.89 pmol/L |
| Parichehr Vahabi Anaraki et al, 2017[36] | −86.25 ± 553.12 vs −88.04 ± 532.1 | NR‡ | 0.58 ± 3.92 vs −0.79 ± 2.08 | NR | NR |
| Zhou et al, 2018[49] | −41.34 ± 130.09 vs 32.14 ± 103.29 | −48.87 ± 186.7 vs 35.22 ± 170.1 | −0.82 ± 2.92 vs −0.12 ± 3.41 | −0.16 ± 1.46 vs −0.02 ± 1.23 pmol/L | 0.1 ± 1.3 vs 0.25 ± 1.5 pmol/L |
| Zuo et al, 2018[45] | −10 ± 6.26 vs 2 ± 10.82 | −11 ± 15.72 vs 1 ± 8.99 | 0.19 ± 0.41 vs 0.09 ± 0.62 | NR | NR |
| Fu et al, 2019[34] | −241.13 ± 237.24 vs 27.49 ± 350.7 | −79.77 ± 86.55 vs 12.3 ± 151.12 | −0.36 ± 1.96 vs 0.42 ± 1.34 | 0.5 ± 3.01 vs 0.17 ± 1.4 pmol/L | 0.12 ± 0.55 vs 0.24 ± 0.55 pmol/L |
| Reza Chahardoli et al, 2019[31] | −13.3 ± 103.32 vs 7.5 ± 133.2 | −52.4 ± 149.95 vs −5.8 ± 160.91 | −1.17 ± 1.84 vs 0.21 ± 1.7 | −0.65 ± 1.71 vs −1.0 ± 1.8 µg/dL | 0 ± 0.35 vs −0.01 ± 0.36 ng/mL |
| Jia, 2020[47] | −358.09 ± 60.43 vs −296.97 ± 61.26 | −55.09 ± 7.36 vs −41.31 ± 7.16 | −36.39 ± 9.67 vs −36.04 ± 10.52 | 11.84 ± 1.87 vs 8.92 ± 1.68 pmol/L | 3.81 ± 0.52 vs 3.02 ± 0.57 pmol/L |
| Xiao et al, 2020[44] | −212.92 ± 2126.76 vs 247.17 ± 2309.03 | −41.73 ± 319.69 vs −36.4 ± 167.9944 | 0.05 ± 0.84 vs 0.25 ± 1.34 | 0.04 ± 0.22 vs 0.06 ± 0.19 ng/dL | −0.04 ± 0.48 vs −0.04 ± 0.39 pg/mL |
| Zhang, 2020[46] | −409.47 ± 48.72 vs −231.43 ± 39.08 | −53.48 ± 7.39 vs −32.84 ± 7.3 | −18.65 ± 6.36 vs −17.26 ± 5.35 | 0.89 ± 0.22 vs 0.37 ± 0.26 pmol/L | 2.19 ± 0.64 vs 1.03 ± 0.7 pmol/L |
| Zhao, 2022[33] | −116.61 ± 913.49 vs 120.11 ± 1179.07 | −84.15 ± 638.56 vs −164.43 ± 727.41 | 0.15 ± 2.47 vs 0.45 ± 1.89 | 1.11 ± 3.01 vs −1.72 ± 2.4 pmol/L | 0.1 ± 0.75 vs −0.17 ± 0.48 pmol/L |
*
T: Treatment Group, C: Control Group.
†
Except for Han et al in 2015,[50] TSH units were reported in mIU/L or µIU/mL. It should be noted that mIU/L is equivalent to µIU/mL.
‡
Not reported.