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. 2023 Dec 29;102(52):e36759. doi: 10.1097/MD.0000000000036759

Table 4.

Effects of treatment duration, vitamin D types, baseline thyroid function, and vitamin D levels on the efficacy of vitamin D therapy in HT.

Included trials Weight% SMD (95% CI) P value I2% Meta-regression P value
TPO-Ab
 Duration of vitamin D supplementation
  ≤12 wk 6[31,34,36,44,49,51] 50.45 −0.454 (−0.749, −0.160) .002 50.5 .03
  >12 wk 6[33,45–48,51] 49.55 −1.741 (−2.750, −0.732) .001 95.1
 Type of vitamin D
  Naive vitamin D (vitamin D2 or D3) 4[33,36,44,49] 34.60 −0.300 (−0.566, −0.034) .027 35.2 .046
  Calcitriol 8[31,34,45–48,50,51] 65.40 −1.522 (−2.277, −0.766) <.001 92.4
 Baseline thyroid function
  Euthyroidism/Subclinical hypothyroidism 5[33,34,44,45,49] 43.13 −0.644 (−1.03, −0.252) .001 74.8 .27
  Hypothyroidism 7[31,36,46–48,50,51] 56.87 −1.420 (−2.415, −0.426) .005 94.7
 Baseline 25(OH)D levels
  Not restricted 3[31,47,50] 24.77 −1.342 (−2.685, 0.000) .05 93.9 .97
  Insufficiency 4[33,34,48,51] 33.03 −0.713 (−1.139, −0.287) .001 56.5
  Deficiency 5[36,44–46,49] 42.20 −1.215 (−2.297, −0.132) .03 95.9
TG-Ab
 Duration of vitamin D supplementation
  ≤12 wk 5[31,34,44,49,51] 45.70 −0.420 (−0.683, −0.156) .002 29.3 .09
  >12 wk 6[33,45–48,50] 54.30 −1.475 (−2.505, −0.446) .005 95.5
 Type of vitamin D
  Naive vitamin D (vitamin D2 or D3) 3[33,44,49] 28.36 −0.138 (−0.505, 0.229) .46 60.1 .06
  Calcitriol 8[31,34,45–48,50,51] 71.64 −1.341 (−2.045, −0.637) <.001 91.5
 Baseline thyroid function
  Euthyroidism/subclinical hypothyroidism 5[33,34,44,45,49] 46.86 −0.400 (−0.783, −−0.017) .04 74.4 .06
  Hypothyroidism 6[31,46–48,50,51] 53.14 −1.513 (−2.469, −0.557) .002 93.0
 Baseline 25(OH)D Levels
  Not restricted 3[31,47,50] 26.72 −1.755 (−3.184, −0.325) .02 94.0 .49
  Insufficiency 4[33,34,48,51] 36.12 −0.373 (−0.831, 0.085) .11 64.0
  Deficiency 4[44–46,49] 37.16 −1.043 (−2.076, −0.010) .048 95.1
FT4
 Duration of vitamin D supplementation
  ≤12 wk 5[31,34,44,49,51] 50.10 0.022 (−0.190, 0.234) .84 0.0 <.001
  >12 wk 5[33,46–48,50] 49.90 1.388 (0.756, 2.201) <.001 86.4
 Type of vitamin D
  Naive vitami> D (vitamin D2 or D3) 3[33,44,49] 31.17 0.274 (−0.448, 0.997) .46 89.3 .26
  Calcitriol 7[31,34,46–48,50,51] 68.83 0.940 (0.241, 1.639) .008 90.8
 Baseline thyroid function
  Euthyroidism/subclinical hypothyroidism 4[33,34,44,49] 41.38 0.240 (−0.289, 0.769) .37 84.1 .10
  Hypothyroidism 6[31,46–48,50,51] 58.62 1.080 (0.343, 1.817) .004 89.7
 Baseline 25(OH)D Levels
  Not restricted 3[31,47,50] 29.67 1.264 (0.297, 2.231) .01 89.0 .39
  Insufficiency 4[33,34,48,51] 39.44 0.433 (−0.061, 0.927) .09 69.0
  Deficiency 3[44,46,49] 30.89 0.642 (−0.687, 1.971) .34 96.4
FT3
 Duration of vitamin D supplementation
  ≤12 wk 5[31,34,44,49,51] 49.92 −0.052 (−0.264, 0.169) .63 0.0 <.001
  >12 wk 5[33,46–48,50] 50.08 1.107 (0.536, 1.677) <.001 84.7
 Type of vitamin D
  Naive vitamin D (vitamin D2 or D3) 3[33,44,49] 31.53 0.098 (−0.226, 0.422) .55 49.0 .18
  Calcitriol 7[31,34,46–48,50,51] 68.47 0.750 (0.116, 1.384) .02 89.4
 Baseline thyroid function
  Euthyroidism/subclinical hypothyroidism 4[33,34,44,49] 41.76 0.029 (−0.246, 0.304) .83 42.7 .02
  Hypothyroidism 6[31,46–48,50,51] 58.24 0.926 (0.339, 1.513) .002 84.6
 Baseline 25(OH)D levels
  Not restricted 3[31,47,50] 29.65 1.018 (0.139, 1.898) .02 87.5 .44
  Insufficiency 4[33,34,48,51] 39.13 0.200 (−0.129, 0.529) .23 33.4
  Deficiency 3[44,46,49] 31.22 0.532 (−0.558, 1.622) .34 95.0