Figure 3. Summary of the radiotherapeutic management and subsequent clinical course.

The figure shows the initiation time of each external-beam radiotherapy, the durations, the timings of MRI evaluation, and the degrees and timings of treatment efficacies and relevant adverse effects. The arrows attached to the notation MRI indicate when the MR images were acquired, and the images from the times indicated by black arrows instead of gray are shown in later figures. The bottom right shows the differences in BED_10/2s between 27 Gy/15 fr and 25 Gy/10 fr. Compared with 25 Gy/10 fr, 27 Gy/15 fr has a similar anti-tumor efficacy while 9% lower late effects.

mo: months; MRI: magnetic resonance imaging; SRS: stereotactic radiosurgery; WBRT: whole-brain radiotherapy; fr: fraction(s); BED_10/2: a biologically effective dose based on the linear-quadratic formula with an alpha/beta ratio of 10/2