Figure 6.

Acute suppression of psoriasis-associated inflammation in K14-IL17A^ind mice upon anti-IL36R therapy. (A) Treatment scheme. (B) Pictures of an IgG or anti-IL36R-treated animal at the starting point of the treatment, during the treatment and at the endpoint. (C) PASI Score of the mice before treatment and at the endpoint. (D) H&E staining of the affected skin areas at the endpoint. Scale: 100 µm. (E) Flow cytometry analysis of skin-infiltrating immune cells from treated animals at endpoint (n = 3 - 5 animals per group). Shown is the relative percentage of positive cells, after pre-gating on viable cells. (F) Gene expression of the skin from IgG or anti-IL36R-treated K14-IL17A^ind mice at the endpoint. Relative gene expression was normalized to Rpl37A. Significance was calculated using a 2-tailed Student’s t-test: * p < 0.05, ** p < 0.01, ns, not significant. Shown is the mean ± SEM.