Table 3.
ROI-to-ROI resting state functional connectivity (rsFC) according to fMRI in individuals with HTT mutations, including those with PreHD and EMHD, and a control group of healthy individuals.
| N | Analysis Unit | Groups | Beta | T | p-unc | p-FDR | Effect size Hedge g |
|---|---|---|---|---|---|---|---|
| 1 | MidFG l – Putamen r |
HC vs. HTT HC HTT |
0.16 0.06 −0.11 |
3.78 1.54 −4.36 |
0.00041 0.137 0.00016 |
0.034 0.23 0.0014 |
1.144 |
| 2 | SFG l – LPFC l |
HC vs. HTT HC HTT |
0.19 0.59 0.4 |
3.47 14.38 10.91 |
0.001 <0.0000 <0.0000 |
0.043 <0.0000 <0.0000 |
0.985 |
| 3 | SFG l –Salience RPFC r |
HC vs. HTT HC HTT |
0.18 0.19 0.01 |
4.12 5.47 0.27 |
0.00014 0.000013 0.79 |
0.022 0.00013 0.91 |
1.106 |
| 4 | SFG l – Salience ACC |
HC vs. HTT HC HTT |
0.22 0.31 0.09 |
3,73 8.93 1.93 |
0.0005 <0.0000 0.064 |
0.026 <0.0000 0.18 |
1.048 |
| 5 | FP r–pSTG l |
HC vs. HTT HC HTT |
0.19 0.2 0.01 |
4.03 6.03 0.29 |
0.0002 0.000003 0.77 |
0.03 0.00002 0.85 |
1.253 |
| 6 | Cereb10 r – SFG l |
HC vs. HTT HC HTT |
0.17 0.18 0.00 |
3.74 5.05 0.16 |
0.00046 0.00004 0.87 |
0.026 0.0003 0.95 |
1.042 |
| 7 | IFG tri l – Cereb10 r |
HC vs. HTT HC HTT |
0.23 0.18 −0.05 |
4.92 4.58 −1.78 |
<0.00001 0.00012 0.09 |
0.0015 0.00055 0.2 |
1.415 |
| 8 | LPFC l – Cereb10 r |
HC vs. HTT HC HTT |
0.19 0.23 0.04 |
4.40 7.93 1.25 |
0.0005 <0.00001 0.22 |
0.0009 <0.00001 0.36 |
1.23 |
| 9 | MidFG l – Cereb10r |
HC vs. HTT HC HTT |
0.2 0.22 0.03 |
4.35 6.84 0.94 |
0.000064 <0.00001 0.35 |
0.011 <0.00001 0.54 |
1.21 |
| 10 | Cereb10 – Language IFG l |
HC vs. HTT HC HTT |
0.2 0.11 −0.1 |
4.26 2.71 −3.4 |
0.00009 0.012 0.002 |
0.014 0.034 0.009 |
1.20 |
| 11 | Hippocampus r – sLOC l |
HC vs. HTT HC HTT |
−0.17 −0.1 0.07 |
−4.06 −3.39 2.38 |
0.00017 0.002 0.02 |
0.027 0.01 0.07 |
0.882 |
| 12 | SPL r – pTFusC l |
HC vs. HTT HC HTT |
−0.21 −0.14 0.08 |
−3.92 −3.46 2.04 |
0.00021 0.0021 0.051 |
0.043 0.011 0.15 |
1.173 |
| 13 | sLOC r – LG l |
HC vs. HTT HC HTT |
−0.21 −0.12 0.09 |
−3.69 −2.91 2.32 |
0.00054 0.0077 0.028 |
0.044 0.039 0.105 |
0.86 |
| 14 | SPL r – Cereb6 r |
HC vs. HTT HC HTT |
−0.21 −0.11 0.1 |
−3.9 −2.52 3.03 |
0.0003 0.019 0.005 |
0.015 0.06 0.032 |
1.07 |
| 15 | SPL r – Cereb6 l |
HC vs. HTT N HTT |
−0.23 −0.13 0.11 |
−3.99 −3.03 2.62 |
0.0002 0.0058 0.014 |
0.015 0.028 0.06 |
1.06 |
| 16 | sLOC r – Cereb6 l |
HC vs. HTT N HTT |
−0.22 −0.17 0.05 |
−3.71 −3.73 1.21 |
0.00051 0.001 0.24 |
0.044 0.009 0.36 |
1.029 |
| 17 | Cereb7 r – pMTG r |
HC vs. HTT HC HTT |
−0.2 −0.07 0.13 |
−3.79 −2.09 3.3 |
0.0004 0.05 0.0027 |
0.04 0.14 0.017 |
1.071 |
| 18 | Cereb7 r – Cereb6 r |
HC vs. HTT HC HTT |
−0.22 −0.05 0.17 |
−3.72 −1.11 4.27 |
0.0005 0.28 0.0002 |
0.04 0.44 0.002 |
0.917 |
| 19 | Cereb9 r –Cereb Ant Network |
HC vs. HTT HC HTT |
−0.22 0.16 0.37 |
−3.88 3.31 11.67 |
0.0003 0.003 <0.00001 |
0.049 0.019 <0.00001 |
1.068 |
MidFG l, Middle Frontal Gyrus left; SFG l, Superior Frontal Gyrus left; LPFC l, Lateral Prefrontal Cortex left; RPFC r, Rostral Prefrontal Cortex right; ACC, Anterior; Cingulate Cortex; FP r, Frontal Pole right; pSTG l, Posterior Superior Temporal Gyrus left; Cereb10 r, Cerebellum 10 right; IFG tri l, Inferior Frontal Gyrus Triangularis left; sLOC l, Superior Lateral Occipital Cortex left; SPL r, Superior Parietal Lobule right; pMTG r, Posterior Middle Temporal Gyrus right; Cereb6 l, Cerebellum 6 left; Cereb 9 r, Cerebellum9 right; Cereb Ant Network, Cerebellar Anterior Network.
HC, resting state functional connectivity (rsFC) characteristics of the healthy control individuals; HTT, rsFC characteristics of the HTT mutation carriers; HC vs. HTT, difference between rsFC characteristics in the healthy controls and in the HTT mutation carriers.
Beta, regression coefficient.