Table 1.
Longitudinal Biomarker Changes
| HIV− | HIV+ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Month 0 N=138 |
Month 6 N=124 |
Month 12 N=106 |
Month 0 N=32 |
Month 6 N=26 |
Month 12 N=25 |
|||||
| d-dimer (ng/mL) | 170.6 (116.8, 338.4) | 127.9 (83.7, 205.2) | 126.2 (82.4, 187.1) | 271.2 (140.1, 362.4) | 160.2 (115.1, 229.8) | 145.9 (109.1, 273.8) | ||||
| Insulin (pmol/L) | 26.8 (19.3, 42.9) | 39.2 (28.0, 67.8) | 36.2 (22.7, 69.3) | 25.6 (19.4, 43.5) | 38.8 (24.3, 53.4) | 34.5 (23.4, 75.9) | ||||
| Glucose (mg/dL) | 87.7 (82.3, 92.7) | 90.6 (86.1, 95.3) | 89.5 (86.4, 95.0) | 85.5 (81.7, 90.1) | 92.7 (88.9, 95.8) | 89.6 (85.5, 95.5) | ||||
| HOMA-IR | 0.8 (0.6, 1.4) | 1.3 (0.9, 2.2) | 1.1 (0.8, 2.3) | 0.8 (0.6, 1.3) | 1.2 (0.8, 1.7) | 1.1 (0.8, 2.6) | ||||
| 6-Month Changes * | 12-Month Changes * | |||||||||
| HIV− | HIV+ | HIV− | HIV+ | |||||||
| Median (IQR) | % | Median (IQR) | % | Median (IQR) | % | Median (IQR) | % | |||
| d-dimer (ng/mL) | −36.5 (−157.4, 30.7) | −21 | −5.5 (−285.8, 36.6) | −2 | −60.6 (−176.3, 10.1) | −36 | −51.1 (−251.6, −0.9) | −19 | ||
| Insulin (pmol/L) | 8.7 (−3.5, 30.8) | +32 | 5.7 (−8.1, 30.7) | +22 | 6.5 (−3.1, 25.4) | +24 | 7.0 (−2.8, 32.8) | +27 | ||
| Glucose (mg/dL) | 3.4 (−3.0, 9.5) | +4 | 5.0 (2.2, 12.5) | +6 | 2.8 (−3.0, 9.1) | +3 | 2.8 (−1.9, 10.0) | +3 | ||
| HOMA-IR | 0.3 (−0.1, 1.1) | +38 | 0.2 (−0.3, 1.1) | +25 | 0.2 (−0.2, 1.2) | +25 | 0.3 (−0.1, 1.4) | +38 | ||
*
P >0.05; HOMA-IR: homeostatic model assessment of insulin resistance; IQR: interquartile range