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. 2023 Jul 24;103(1):176–187. doi: 10.1111/aogs.14637

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© 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Intention‐to‐treat analyses on treatment effect of metformin on anthropometric z‐scores of offspring born to women with PCOS, stratified according to maternal androgen phenotype. Treatment effect of metformin stratified by maternal androgenic phenotype on head circumference (left panel), birth length (middle) and birthweight (right). The estimated effect of metformin among hyperandrogen (mid‐blue) and normoandrogen (dark blue) is shown as a mean different in z‐score with 95% confidence interval. The pink line and shaded area represent the estimated metformin effect in the whole group without stratification. PCOS = polycystic ovary syndrome.