Table 1.
PACAP related gene expression in the ACC and DLPFC in bipolar disorder (BD) and major depressive disorder (MDD) patients compared to matched controls
| DLPFC | ACC | |||||
|---|---|---|---|---|---|---|
| Fold change | p value | BH-adj | Fold change | p value | BH-adj | |
| Bipolar disorder | ||||||
| Target genes | ||||||
| PAC1 | −1.24 | 0.36 | −1.02 | 0.67 | ||
| VPAC2 | −1.46 | 0.51 | −1.86 | 0.001 | 0.004 | |
| PACAP | −1.95 | 0.01 | 0.034 | −1.42 | 0.048 | 0.08 |
| VPAC1 | −1.42 | 0.003 | 0.013 | −1.49 | 0.000048 | 0.0002 |
| CD38 | −1.17 | 0.36 | −1.34 | 0.38 | ||
| Major depressive disorder | ||||||
| Target genes | ||||||
| PAC1 | 2.0 | 0.075 | 1 | 0.57 | ||
| VPAC2 | 1.3 | 0.24 | −1.25 | 0.4 | ||
| PACAP | 1.98 | 0.004 | 0.018 | 1.16 | 0.37 | |
| VPAC1 | 1.73 | 0.048 | 0.12 | −1.1 | 0.61 | |
| CD38 | −1.06 | 0.42 | 1.36 | 0.87 | ||
ACC, anterior cingulate cortex; BH-adj-P, p value following Benjamini–Hochberg's adjustment; CD38, cyclic adenosine diphosphate (ADP) ribose hydrolase; DLPFC, dorsolateral prefrontal cortex, – (before fold change), lower expression in BD; MDD, major depressive disorder; PAC1, PACAP type I receptor; VPAC1 and VPAC2; vasoactive intestinal peptide (VIP) receptors I and II.