Table 3.

Relation to psychotic features

Fold change				Global-p	BHajd-p	BHajd-p
	CTR v. MDD-NP	CTR v. MDD-P	MDD-NP v. MDD-P			CTR v. MDD-NP	CTR v. MDD-P	MDD-NP v. MDD-P
DLPFC target genes
PAC1	2.08	1.99	−1.11	0.19	0.24
VPAC2	−1.07	1.97	2.12	0.14	0.24
PACAP	1.29	2.46	1.90	0.0009	0.004	0.17*	6.00×10−5*	0.003*
VPAC1	1.65	1.70	1.03	0.17	0.24
CD38	−1.83	1.13	1.33	0.74	0.74
ACC target genes
PAC1	−1.27	−1.03	1.23	0.67	0.86
VPAC2	−1.85	−1.72	1.08	0.45	0.86
PACAP	1.08	−1.36	−1.46	0.59	0.86
VPAC1	−1.27	−1.03	1.24	0.69	0.86
CD38	−1.09	1.02	1.12	0.97	0.97

PACAP related gene expression in the ACC and DLPFC in MDD and BD patients with (MDD-P) and without (MDD-NP, BD-NP) psychotic features and their matched controls (CTR): ACC, anterior cingulate cortex; BD, bipolar disorder; BD-NP, bipolar disorder patients that died of natural causes; BD-S, bipolar disorder patients that completed suicide; BHadj-P, p value of Benjamini–Hochberg's adjustment; Ctr: control; CD38, cyclic adenosine diphosphate (ADP) ribose hydrolase; DLPFC, dorsolateral prefrontal cortex; MDD, major depressive disorder; PAC1, PACAP type I receptor; VPAC1 and VPAC2; vasoactive intestinal peptide (VIP) receptors I and II. *: Correction not necessary.