Sprague Dawley (SD) rats |
36 rats were selected and divided in desired number of groups.Group I was given normal chow diet-fed (NC), Group II was given high cholesterol diet (HCD), Group III was given HCD + Simvastatin, and the rest three groups were given HCD + ZACAH extracts in varying doses (1, 3 and 5 mg/kg body weight) for 18 weeks. Simvastatin was used as control. |
Administration of ZACAH extracts reduced the level of total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), and amplified the level of HDL.It exhibited therapeutic effects in rats fed with HCD. |
It has been concluded that ZACAH extracts enhanced hyperlipidaemia inrats. Therefore, ZACAH extracts can be employedto treat hyperlipidaemia. |
[67] |