Table 1.

Representative drugs targeting immune regulation in neutrophils.

Principle	Classification	Intervention/Drugs	Mechanisms	References
Targeting the glucose metabolism pathway.	Glycolytic agonist	NA-11	Activates the enzyme PFKL and redirects the metabolic flux from the pentose phosphate pathway back to the glycolytic pathway, consequently inhibiting the NOX 2-dependent oxidative burst in neutrophils.	(64)
	PPP inhibitor	G6PDi	Suppresses G6PD, thus blocking the PPP and respiratory burst	(62)
Targeting inflammasome	GSDMD inhibitor	Disulfiram	Inhibits GSDMD-mediated inflammasome activation	(112, 113)
		ivermectin	inhibits GSDMD oligomerization	(114)
	NE inhibitor	Necrostatin-1	Inhibition of NE activation and the subsequent activation of GSDMD by NE	(115, 116)
Targeting chemokines/cytokines and neutrophil receptors	Human monoclonal antibody against IL-8	HuMab 10F8	Blocks IL-8 to inhibit neutrophil migration	(117)
	Inhibitor of CXCR1 and CXCR2 receptors	Repertaxin	blocks CXCL 1/2 signaling in neutrophils	(118)
	IL-1 receptor inhibitor	IL-1 Ra	Blocks the signaling of IL-1 β in neutrophils	(119, 120)
	Human antibody against N-terminal domain of MK	anti-N-MK	Prevents neutrophil migration	(121)