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. 2023 Nov 28;79:101841. doi: 10.1016/j.molmet.2023.101841

Figure 6.

Figure 6

FXR activation prevents renal lipid accumulation and protects against renal fibrosis in HFD mice. (A) Oil red O staining of kidney sections. (B–C) Representative micrographs display the induction of localization of fibronectin and α-SMA in HFD mice. Kidneys from control, HFD, CDCA and INT-747 group for 20 weeks were stained immunohistochemically for fibronectin and α-SMA protein. Representative images of Masson staining (D) and Sirius red staining (E). The positive area of Masson and Sirius red were calculated (F) (n = 5). Values shown are means ± S.E.M. ∗p < 0.05.