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Application of natural polymer microspheres to alleviate the inflammation in IVDD. a. Injectable circRNA-silencing-hydrogel microspheres for the regulation of ECM metabolism. Reproduced with permission from Ref. [234]. b. Microparticle encapsulation of EGCG inhibits the expression of inflammatory mediators. Reproduced with permission from Ref. [236]. c. Nanozyme-functionalized hydrogel microsphere. Reproduced with permission from Ref. [232].
