Figure 4.

Corneal irregularity analysis in DED mice after DED induction and during treatment. (A) Ring-light reflection images of the corneas of normal and DED mice immediately after DED induction and on days 3, 7, and 14 of treatment with NS and CsA. (B) Corneal irregularity scores between normal and DED mice and the longitudinal changes in irregularity scores in the NS-treated and CsA-treated DED groups. Data are presented as the mean ± standard deviation, and normal and DED groups were compared with the t test and Mann–Whitney U test. Longitudinal data on days 3, 7, and 14 were compared with the multiple t test. Statistical significance was assessed using the Holm–Sidak method, N = 7, *P < 0.05.