Table 1.
Pharmacokinetic (PK) parameters of ketamine and downstream metabolites in the plasma and CSF of healthy volunteers after IV ketamine infusion (0.5 mg/kg) over 40 min
| Metabolite | PK Parameter | CSF |
Plasma |
||||
|---|---|---|---|---|---|---|---|
| n | Median [IQR] | Range | n | Median [IQR] | Range | ||
| K | Cmax (ng/mL) | 9 | 42.36 [39.25, 89] | 32.39–94.47 | 8 | 112.87 [91.52, 155] | 85.34–247.51 |
| K | Tmax (min) | 9 | 120 [40, 120] | 40–120 | 8 | 40 [40, 40] | 40–40 |
| K | AUC (ng.min/mL) | 9 | 2742.64 [2131.41, 2773] | 1695.98–3022.87 | 8 | 2990.36 [2523.72, 3286] | 2104.85–4006.24 |
| K | half.life (min) | 8 | 545.5 [403.45, 689] | 355.95–849.07 | 8 | 592.99 [449.01, 765] | 208.78–898.04 |
| NK | Cmax (ng/mL) | 9 | 25.26 [20.93, 32] | 16.3–42.15 | 8 | 59.27 [48.39, 72] | 35.21–78.34 |
| NK | Tmax (min) | 9 | 120 [120, 120] | 120–230 | 8 | 120 [100, 148] | 40–230 |
| NK | AUC (ng.min/mL) | 9 | 3997.96 [3379.25, 4342] | 1840.97–4393.29 | 8 | 4820.98 [3949.2, 5331] | 2389.11–5592.8 |
| NK | half.life | 9 | 778.73 [558.11, 1548] | 121.71–1928.62 | 8 | 1200.23 [976.09, 1586] | 606.23–4202.75 |
| HNK | Cmax (ng/mL) | 9 | 39.26 [30.03, 49] | 9.02–65.36 | 8 | 46.19 [28.06, 58] | 12.02–70.56 |
| HNK | Tmax (min) | 9 | 360 [230, 360] | 230–600 | 8 | 295 [230, 420] | 230–600 |
| HNK | AUC (ng.min/mL) | 9 | 5023.72 [4211.75, 5121] | 2588.38–5451.1 | 8 | 5126.06 [4250.94, 5339] | 2812.12–5947.81 |
| HNK | half.life (min) | 9 | 2267.35 [1851.63, 2819] | 1290.69–3593.57 | 7 | 2215.58 [2172.04, 2415] | 1190.54–3248.11 |
Cmax, maximum concentration; Tmax, timepoint of maxium concentration (minutes).