REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, peptides, and recombinant proteins
ammonium acetate	Sigma	A1542
acetonitrile, LC-MS grade	Sigma	AX0156-1
isopropanol, Lc-MS grade	Sigma	1027814000
(2R,6R)-HNK	Tocris	6094
(2S,6S)-HNK	Tocris	6095
(R)-NK	Tocris	5996
(S)-NK	Tocris	6112
Ketamine	Cerilliant	K-002
Ketamine -d4 HCl	Cerilliant	K-006
Norketamine-d4	Cerilliant	N-037
Critical commercial assays
Mercodia ultrasensitive insulin ELISA kit	Mercodia	10-1132-01
Olink Explore 384 Inflammation I Reagent Kit	Olink Proteomics	91101
Olink Explore 384 Oncology I Reagent Kit	Olink Proteomics	91102
Olink Explore 384 Cardiometabolic I Reagent Kit	Olink Proteomics	91103
Olink Explore Neurology I Reagent Kit	Olink Proteomics	91104
Software and algorithms
PK version 1.3.5, package for R	Jaki T, Wolfsegger MJ. Estimation of pharmacokinetic parameters with the R package PK. Pharm Stat. 2011; 10(3):284-8.	NA
lme4 version 1.1.33, package for R	Bates D, Machler M, Bolker BM, Walker SC. Fitting Linear Mixed-Effects Models Using lme4. J Stat Softw. 2015; 67(1):1-48	NA
R version 4.3.0	R Core Team (2023). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria
Other
Eclipse XDB-C18 guard column (4.6 mm × 12.5 mm)	Agilent	820950–925
Lux® Amylose-2, LC Column (150 × 4.6 mm, 3um)	Phenomenex	00F-4471-EO
Varian Pursuit XRs 5 C18 (250 × 4.0 mm ID, 5 μm)	Agilent	A6000250X040
NovaSeq 6000 SP Reagent Kit v 1.5 (100 cycles),	Illumina	20028401