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. 2023 Dec 14;14:1239151. doi: 10.3389/fimmu.2023.1239151

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Copyright © 2023 Chalmers, Kettritz and Korkmaz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutrophilic Response to Inflammation and Infection. NSP proenzymes are activated by DPP1 to their catalytically active forms in promyelocytes during neutrophil differentiation in the bone marrow. Neutrophils migrate via the bloodstream to sites of inflammation and infection where activated NSPs are released and other critical neutrophilic functions are triggered. NSP activity is regulated by endogenous inhibitors (serpins) such as AAT, alpha-1 antitrypsin. DPP, dipeptidyl peptidase; MMP, matrix metalloproteinase; MPO, myeloperoxidase; NE, neutrophil elastase; NET, neutrophil extracellular trap; NSP, neutrophil serine protease.