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LC-MS analysis of FTase-catalyzed prenylation of K-Ras4B with 1 to yield full length protein incorporating a diazirine isoprenoid. A) LC-MS chromatogram (TIC) showing the formation of K-Ras4B modified with 1. B) MS of K-Ras4B modified with 1 obtained after yFTase (MS is from peak at 3.2 min in LC-MS chromatogram).
