Table 2. Detail information of corresponding studies.
| Exposure or outcome | Unit | Participants included in analysis | Adjustment | SNPs (selected instrumental variants) | F-statistic | PubMed ID |
| Smoking initiation | SD in prevalence of smoking initiation | 311,629 ever smokers and 321,173 never smokers of European-descent | Age, sex, and the first ten genetic principal components | 93 | 30–145 | 30643251 |
| Age of smoking initiation | SD | 341,427 European-descent individuals | Age, sex, and the first ten genetic principal components | 7 | 31–53 | 30643251 |
| Alcoholic drinks per week | SD | 335,394 European-descent individuals | Age, sex, and the first ten genetic principal components | 35 | 30–927 | 30643251 |
| MVPA | Dichotomous outcome (defined as at least 30 min per week of MVPA yes/no) | 703,901 individuals (94.0% European, 2.1% African, 0.8% East Asian, 1.3% South Asian ancestries, and 1.9% Hispanic) | Age, sex and the first ten genetic principal components | 9 | 31–91 | 36071172 |
| Leisure screen time | SD | 703,901 individuals (94.0% European, 2.1% African, 0.8% East Asian, 1.3% South Asian ancestries, and 1.9% Hispanic) | Age, sex and the first ten genetic principal components | 89 | 27–111 | 36071172 |
| Birth weight | SD | 143,677 European-descent individuals | Gestational age | 50 | 30–180 | 27680694 |
| BMI | SD (>30 kg/m2) | 322,154 European-descent individuals | Age, age squared, sex, and the first four genetic principal components | 69 | 29–696 | 25673413 |
| Waist circumference | SD | 210,088 European-descent individuals | Age, age squared, and sex | 42 | 29–447 | 25673412 |
| Frailty index | SD | 164,610 UK Biobank participants and 84,819 TwinGene participants of European descent | Age, sex, and the first ten genetic principal components | − | − | 34431594 |
Abbreviations: SNPs: single-nucleotide polymorphisms; ID: identifier; SD: standard deviation; MVPA: moderate-to-vigorous intensity physical activity during leisure time; BMI: body mass index.