Table 2.
ALS risk associated with 5-year residential history based pesticide exposure estimates.
| Pesticide | median cutpoint (kg) | Controls n = 1949 |
ALS patients n = 500 |
Univariate P-value |
Multivariable Odds Ratio (OR)* |
95 % CI |
|---|---|---|---|---|---|---|
| MCPB | ≤0.001 | 1936 (99.3) | 489 (97.8) | 0.004 | ||
| >0.001 | 13 (0.7) | 11 (2.2) | 3.71 | 1.61 – 8.44 | ||
| terbacil | ≤2.48 | 1017 (52.2) | 148 (29.6) | <0.001 | ||
| >2.48 | 932 (47.8) | 352 (70.4) | 2.62 | 2.12 – 3.25 | ||
| carbaryl | ≤93.3 | 977 (50.1) | 195 (39.0) | <0.001 | ||
| >93.3 | 972 (49.9) | 305 (61.0) | 1.59 | 1.30 – 1.94 | ||
| chlorpyrifos | ≤438 | 975 (50.0) | 205 (41.0) | <0.001 | ||
| >438 | 974 (50.0) | 295 (59.0) | 1.46 | 1.19 – 1.78 | ||
| 2,4-D | ≤1340 | 975 (50.0) | 188 (37.6) | <0.001 | ||
| >1340 | 974 (50.0) | 312 (62.4) | 1.68 | 1.38–2.06 | ||
| glyphosate | ≤9090 | 975 (50.0) | 167 (33.4) | <0.001 | ||
| >9090 | 974 (50.0) | 333 (66.6) | 2.02 | 1.64 – 2.49 | ||
| chlorothalonil | ≤212 | 979 (50.2) | 245 (49.0) | 0.66 | ||
| >212 | 970 (49.8) | 255 (51.0) | 1.05 | 0.86 – 1.27 | ||
| captan | ≤298 | 975 (50.0) | 261 (52.2) | 0.42 | ||
| >298 | 974 (50.0) | 239 (47.8) | 0.91 | 0.75 – 1.11 | ||
| mancozeb | ≤189 | 975 (50.0) | 255 (51.0) | 0.74 | ||
| >189 | 974 (50.0) | 245 (49.0) | 0.96 | 0.79 – 1.18 | ||
| hymexazol | ≤0.001 | 1945 (99.8) | 497 (99.4) | 0.32 | ||
| >0.001 | 4 (0.2) | 3 (0.6) | 3.09 | 0.60 – 14.31 | ||
| permethrin | ≤58.5 | 975 (50.0) | 160 (32.0) | <0.001 | ||
| >58.5 | 974 (50.0) | 340 (68.0) | 2.14 | 1.74 – 2.64 | ||
| paraquat | ≤348 | 981 (50.3) | 200 (40.0) | <0.001 | ||
| >348 | 968 (49.7) | 300 (60.0) | 1.53 | 1.25–1.87 |
*
Adjusted for age and sex.