Table 3.
Pesticide groups enriched with positive ALS association.
| Mechanism of action | Score | P-value | Pesticides associated with ALS risk | |
|---|---|---|---|---|
| Fungicide Group | ||||
| Dithiocarbamates | multi-site contact activity | 1.33 | 0.02 | FERBAM, MANEB, METIRAM, THIRAM, ZINEB, ZIRAM |
| Anilino-Pyrimidines | methionine biosynthesis | 1.73 | 0.035 | CYPRODINIL, PYRIMETHANIL |
| Benzimidazoles | ß-tubulin assembly in mitosis | 1.02 | 0.04 | BENOMYL, THIABENDAZOLE, THIOPHANATE-METHYL |
| Phosphonates | host plant defense induction | 1.58 | 0.04 | FOSETYL-AL, PHOSPHOROUS ACID/SALTS |
| Herbicide Group | ||||
| Pyridiniums | Photosystem I Electron Diversion | 0.98 | 0.045 | DIQUAT, PARAQUAT |