Figure 6. Scheme for the immune-activating state induced by SMARCA4 down-regulation in SMARCA4-mutant cancers. Briefly, down-regulations of 3 genes in the TME, namely MYC, AURKB and IL20R, might trigger TIL (effector T-cell and mature B-cell) induction, cell cycle arrest and chromatin remodeling insufficiency, which can contribute to immune activation. In addition, activation of natural killer (NK) cells and dendritic cells (DCs) and inhibition of myeloid derived suppressor cells (MDSCs) and neutrophils in blood may be induced.