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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Hum Pathol. 2022 Nov 9;131:79–86. doi: 10.1016/j.humpath.2022.11.003

Table 2.

ALT positive cases

Tumor type ALT-FISH ATRX immunostain Key Morphology findings
Cholangiocarcinoma Positive Retained nuclear staining Large duct pattern with striking nuclear anaplasia
Combined hepatocellular and cholangiocarcinoma Positive in hepatocellular component and in cholangiocarcinoma component Not tested Hepatocellular carcinoma: moderately abundant eosinophilic to focally clear cytoplasm; patchy striking nuclear atypia
Cholangiocarcinoma: small duct pattern; nuclear cytology homogenous without striking nuclear atypia
Carcinosarcoma Positive in hepatocellular carcinoma component
Equivocal positive in sarcoma component		 Retained nuclear staining Hepatocellular carcinoma: moderately abundant eosinophilic to focally clear cytoplasm; patchy striking nuclear atypia
Sarcoma: Undifferentiated sarcoma
Angiosarcoma Case 1 Positive Retained nuclear staining Epithelioid, multinucleated tumor giant cells
Angiosarcoma Case 2 Positive Retained nuclear staining Vasoformative