Table 3.

Post-Treatment Minus Baseline Change in VMS and Sleep Outcomes by Satisfaction with VMS Control/Relief and Desired Continuation

Outcome Change	Satisfied with VMS control/relief					Desire to continue study medication/pills
	Yes (n=426)		No (n=426)			Yes (n=385)		No (n=457)
	Mean	SD	Mean	SD	p-value	Mean	SD	Mean	SD	p-value
VMS frequency per day	−4.9	3.8	−1.5	3.3	<0.001	−4.7	4.2	−1.9	3.2	<0.001
VMS severity (1–3)	−0.6	0.6	−0.2	0.5	<0.001	−0.6	0.5	−0.2	0.5	<0.001
VMS bother (1–4)	−0.8	0.7	−0.2	0.5	<0.001	−0.8	0.7	−0.3	0.6	<0.001
VMS interference (HFRDIS)	−2.3	2.3	−0.7	1.9	<0.001	−2.3	2.4	−0.9	1.8	<0.001
VMS interference (HFI)	−3.0	2.6	−1.1	2.2	<0.001	−3.0	2.7	−1.2	2.2	<0.001
Insomnia severity (ISI)	−5.1	5.0	−2.5	4.3	<0.001	−5.1	5.2	−2.7	4.3	<0.001
Sleep quality/disturbance (PSQI)	−2.5	3.0	−1.3	2.7	<0.001	−2.7	3.0	−1.3	2.7	<0.001

HFI = Hot Flash Interference Scale 3 items, HFRDIS= Hot Flash Related Daily Interference Scale 10 items; ISI=Insomnia Severity Index; PSQI = Pittsburgh Sleep Quality Index; SD=standard deviation; VMS=vasomotor symptoms.