Table 5.
Post-Treatment Minus Baseline Change in VMS and Sleep Outcomes by Perceived Pill Group
| Outcome Change | Active pill (n=331) | Inactive or placebo pill (n=274) | Don’t know (n=250) | ||||
|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | p-value | |
| VMS frequency per day | −4.4a | 4.0 | −1.3b | 3.2 | −3.4c | 3.8 | <0.001 |
| VMS severity (1–3) | −0.6a | 0.6 | −0.2b | 0.5 | −0.4c | 0.5 | <0.001 |
| VMS bother (1–4) | −0.7a | 0.7 | −0.2b | 0.5 | −0.5c | 0.6 | <0.001 |
| VMS interference (HFRDIS) | −2.0a | 2.2 | −0.9b | 1.8 | −1.6c | 2.4 | <0.001 |
| VMS interference (HFI) | −2.7a | 2.7 | −1.2b | 2.2 | −2.1c | 2.6 | <0.001 |
| Insomnia severity (ISI) | −2.4a | 2.9 | −1.3b | 2.8 | −1.8b | 3.0 | <0.001 |
| Sleep quality/disturbance (PSQI) | −4.4a | 5.0 | −2.8b | 4.6 | −4.0a | 4.8 | <0.001 |
a,b,c
Differing superscripts within a row denote significant group differences in post-hoc pairwise comparisons.
HFI = Hot Flash Interference Scale 3 items, HFRDIS= Hot Flash Related Daily Interference Scale 10 items; ISI=Insomnia Severity Index; PSQI = Pittsburgh Sleep Quality Index; SD=standard deviation; VMS=vasomotor symptoms.