TABLE 2.
Characteristics of KEEPS continuation participants at KEEPS baseline by randomization group
| All (n = 299) | oCEE (n = 90) | tE2 (n = 96) | Placebo (n = 113) | Overall P value | |
|---|---|---|---|---|---|
| Age (y) | 54 (2) | 54 (3) | 54 (2) | 54 (2) | 0.77 |
| BMI (kg/m2) | 25.9 (4.3) | 26.1 (4.4) | 25.4 (4.2) | 26.2 (4.3) | 0.39 |
| Waist/hip ratio | 0.8 (0.1) | 0.8 (0.1) | 0.8 (0.1) | 0.8 (0.1) | 0.84 |
| Diabetes, n (%) | 0 | 0 | 0 | 0 | |
| Smoker, n (%) | 12 (4) | 1 (1) | 5 (5) | 6 (5) | 0.22 |
| Systolic BP (mm Hg) | 117 (14) | 118 (14) | 116 (15) | 118 (15) | 0.53 |
| Diastolic BP (mm Hg) | 74 (9) | 75 (8) | 73 (9) | 75 (9) | 0.17 |
| Total cholesterol (mg/dL) | 209 (33) | 213 (32) | 207 (33) | 208 (36) | 0.43 |
| HDL-C (mg/dL) | 73 (14) | 74 (14) | 75 (15) | 72 (14) | 0.39 |
| LDL-C (mg/dL) | 113 (29) | 117 (30) | 110 (29) | 112 (27) | 0.24 |
| Triglycerides (mg/dL) | 85 (55) | 83 (61) | 81 (44) | 88 (59) | 0.64 |
| Glucose (mg/dL) | 80 (9) | 80 (10) | 79 (8) | 80 (10) | 0.96 |
| Insulin (mcU/mL) | 6.1 (9.4) | 4.8 (3.9) | 6.7 (13.8) | 6.7 (7.8) | 0.28 |
| HOMA-IR | 1.3 (2.1) | 1.0 (0.8) | 1.4 (3.1) | 1.4 (1.7) | 0.46a |
| Heart attack or angina, n (%) | 0 | 0 | 0 | 0 | |
| Congestive heart failure, n (%) | 0 | 0 | 0 | 0 | |
| Stroke, n (%) | 0 | 0 | 0 | 0 |
Characteristics represent data collected between years 2005 and 2008 before the time when women were recontacted for the KEEPS continuation study. Data shown are mean (SD) or n (%). Groupwise P values comparing treatment to placebo are from Fisher exact test or analysis of variance followed by Tukey pairwise tests, as appropriate.
BMI, body mass index; BP, blood pressure; HDL-C, high-density lipoprotein cholesterol; KEEPS, Kronos Early Estrogen Prevention Study; LDL-C, low-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance.
aP value is from log-transformed HOMA-IR.