Figure 4.

²H₂O-labeling patterns for amino acids and organic acids in LD and SD from 0 to 24 h. A) Amino acid labeling patterns. B) Organic acid labeling patterns. MIDs are shown as points with error bars (n = 3, ±Sd). Nominal masses of M0 mass isotopologs are shown in parentheses. m0: unlabeled molecule with no isotopic atoms. m1: 1 atom isotopically labeled. m2: 2 atoms isotopically labeled. ALA, alanine; ASN, asparagine; ASP, aspartate; CIT, citrate; FUM, fumarate; GLN, glutamine; GLY, glycine; MAL, malate; SER, serine; SUC, succinate; THR, threonine. All abbreviations are shown in Supplemental Table S10.