TABLE 1.

Neutralizing antibody titers in IL-12p35^−/− and IL-12p40^−/− vaccinated mice^a

Vaccine	Mean neutralizing antibody titer ± SEMb
	IL-12p35−/−	IL-12p40−/−	BALB/c
KOS	498 ± 67	767 ± 98	513 ± 50
Mock	21 ± 8	29 ± 6	18 ± 11

^aMice were vaccinated i.p. three times with 2 × 10⁵ PFU of HSV-1 strain KOS and were bled 3 weeks after the third vaccination as described in Materials and Methods. Neutralization titers are expressed as the reciprocal of the geometric means.

^bP values, determined by using the Student t test, were as follows: IL-12p35^−/−, P < 0.0001 (KOS versus mock); IL-12p40^−/−, P < 0.0001 (KOS versus mock) and P = 0.04 (versus vaccinated IL-12p35^−/−); and BALB/c, P < 0.0001 (KOS versus mock), P = 0.9 (versus vaccinated IL-12p35^−/−), and P = 0.05 (versus vaccinated IL-12p40^−/−).