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. 2023 Dec 29;13:23103. doi: 10.1038/s41598-023-50848-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CPEB2 inhibits glioma growth partially through upregulating p21 in vivo. (A) Scheme of the experimental design. (B) The indicated stable expressing cells used for the in vivo study were confirmed by western blot analysis. (C) Images of the tumors from the indicated group. (D) Time course of tumor growth in mice. The indicated stable expressing cells were injected into nude mice, and tumor volumes were measured every 4 days. (E) Tumor weights were measured after the tumors were surgically dissected. (F,G) Ki-67 and cleaved-caspase 3 (C-caspaase 3) expression of the indicated tumor sections were detected by immunochemistry staining. Representative images were shown (×400 magnification), and ki-67 positive cellular index was defined as the presence of nuclear staining. (H) A schematic diagram of the function of CPEB2 in glioma. All values are mean ± SEM. Two way ANOVA followed by Tukey's multiple comparison test or Student t-tests were used. **P < 0.01, ***P < 0.001 versus vector and ^###P < 0.001 versus shCPEB2. SEM standard error of the mean.