Table 1.
Patient cohort for ALI cultures.
| Non-smoker controls (n = 5) | Smoker controls (n = 7) | COPD1-2 (n = 7) | COPD3-4 (n = 7) | ||
|---|---|---|---|---|---|
| N (male/female) | 5 (2/3) | 7 (6/1) | 7 (4/3) | 7 (2/5) | ns |
| Age (yr) | 67.8 ± 13.8 | 66.1 ± 11.1 | 66.4 ± 12.3 | 58.8 ± 5.7 | ns |
| Smoking history (never/former/current n) | 5/0/0 | 0/5/2 | 0/1/6 | 0/7/0 | P = 0.001 |
| Pack-years | NA | 28.6 ± 14.4 | 43.5 ± 15.6 | 34.4 ± 10.8 | ns |
| If applicable, duration since smoking cessation (months) | NA | 73.1 ± 98.4 | 14.5 ± 23.9 | 75.4 ± 57.0 | ns |
| FEV1 (% of PV) | 100.0 ± 12.7 | 94.5 ± 18.9 | 77.3 ± 10.4a,b | 21.0 ± 2.3a,b,c | P < 0.0001 |
| FEV1/VC ratio (%) | 81.8 ± 4.7 | 83.4 ± 6.5 | 54.6 ± 6.9a,b | 31.6 ± 5.9a,b,c | P < 0.0001 |
| DLCO (% of PV) | 97.4 ± 13.0 | 90.2 ± 13.7 | 59.2 ± 13.1a | 36.6 ± 8.0a,b,c | P < 0.0001 |
| BMI (kg.m−2) | 28.9 ± 3.5 | 26.6 ± 5.5 | 23.7 ± 5.1 | 22.5 ± 3.7 | ns |
| Inhaled corticosteroids (n/total N) | 0/5 | 1/7 | 0/7 | 7/7 | P < 0.0001 |
| Surgical indication | P < 0.0001d | ||||
| Neoplasia | 4/5 | 8/8 | 5/6 | 0/6 | |
| SCC | 0 | 2 | 1 | 0 | |
| AC | 2 | 4 | 3 | 0 | |
| Carcinoid tumor | 2 | 1 | 0 | 0 | |
| Pulmonary metastasis of other cancers | 0 | 1 | 1 | 0 | |
| Lung transplant | 0 | 0 | 0 | 6 | |
| Other | 0 | 0 | 1 | 0 | |
| Declined lung donor | 1 | 0 | 0 | 0 |
Data are presented as mean ± SD, unless otherwise stated. Demographic data, lung function tests, smoking history, and inhaled corticotherapy are stated for the patient groups, classified according to smoking history and the presence and severity of airflow limitation. AC, adenocarcinoma; ALI, air/liquid interface; BMI, body mass index; COPD, chronic obstructive pulmonary disease; DLCO, diffusing capacity of the lung for CO; FEV1, forced expiratory volume in 1 s; PV, predicted values; SCC, squamous cell cancer; SD, standard deviation; VC, vital capacity; ns, not significant.
P < 0.05 compared to non-smoker controls.
P < 0.05 compared to smoker controls.
P < 0.05 compared to COPD stage 1–2 patients.
Comparison between “Neoplasia,” “Lung transplant,” and “Other.”