TABLE 5.
Frequencies of optimized epitope and variant epitope sequences in subject R before and after initiation of therapy for epitopes RLRPGGKKK(p17 20-28) and TAFTIPSI(pol 295-302) based on viral RNA sequencing
| Time (wks) in therapy | Viral load | Sequence (no. of clones/total)
|
|
|---|---|---|---|
| RLRPGGKKK | TAFTIPSI | ||
| 0 | 98,597 | RLRPGGKKK (6/20) | TAFTIPSI (0/24) |
| --------Q (11/20) | -------T (24/24) | ||
| --------R (3/20) | -------M (0/24) | ||
| 9.5 | 478 | ||
| 14 | NDa | RLRPGGKKK (14/16) | TAFTIPSI (14/14) |
| --------Q (0/16) | -------T (0/14) | ||
| --------R (2/16) | -------M (0/14) | ||
| 19 | <400 | RLRPGGKKK (0/15) | TAFTIPSI (0/18) |
| --------Q (15/15) | -------T (0/18) | ||
| --------R (0/15) | -------M (18/18) | ||
ND, not determined.