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TABLE 5.

Frequencies of optimized epitope and variant epitope sequences in subject R before and after initiation of therapy for epitopes RLRPGGKKK(p17 20-28) and TAFTIPSI(pol 295-302) based on viral RNA sequencing

Time (wks) in therapy Viral load Sequence (no. of clones/total)
RLRPGGKKK TAFTIPSI
0 98,597 RLRPGGKKK (6/20) TAFTIPSI (0/24)
--------Q (11/20) -------T (24/24)
--------R (3/20) -------M (0/24)
9.5 478
14 NDa RLRPGGKKK (14/16) TAFTIPSI (14/14)
--------Q (0/16) -------T (0/14)
--------R (2/16) -------M (0/14)
19 <400 RLRPGGKKK (0/15) TAFTIPSI (0/18)
--------Q (15/15) -------T (0/18)
--------R (0/15) -------M (18/18)
a

ND, not determined.