FIG. 4.

Depletion of CD4⁺ CD25⁺ cells enhances antiviral function of HBV-specific CD8⁺ cells. Visualization of IFN-γ production of tetramer⁺ CD8 cells expanded in the presence or absence of CD4⁺ CD25⁺ cells. Dot plots represent live gated CD8⁺ cells stained with Tc18-27 and anti-IFN-γ antibodies. Numbers indicate the proportion of tetramer⁺ CD8⁺ cells producing IFN-γ. Results were confirmed in three out of three different subjects tested.