Table 2.
Univariate and multivariate Cox proportional hazard analyses of YTHDF2 expression.
| Variable | Number | Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|---|---|
| HR (95 % CI) | P value | HR (95 % CI) | P value | |||
| Gender | ||||||
| Male | 252 | Reference | ||||
| Female | 121 | 1.261 (0.885–1.796) | 0.200 | |||
| Age | ||||||
| ≤60 | 177 | Reference | ||||
| >60 | 196 | 1.205 (0.850–1.708) | 0.295 | |||
| Race | ||||||
| White | 185 | Reference | ||||
| Black or African American | 17 | 1.198 (0.520–2.760) | 0.672 | |||
| Asian | 159 | 0.756 (0.519–1.101) | 0.144 | |||
| YTHDF2 | ||||||
| Low | 187 | Reference | ||||
| High | 186 | 1.643 (1.160–2.328) | 0.005 | 1.495 (1.043–2.142) | 0.028 | |
| T stage | ||||||
| T1 | 183 | Reference | ||||
| T2 | 94 | 1.431 (0.902–2.268) | 0.128 | 1.320 (0.828–2.105) | 0.243 | |
| T3 | 80 | 2.674 (1.761–4.060) | <0.001 | 2.442 (1.596–3.737) | <0.001 | |
| T4 | 13 | 5.386 (2.690–10.784) | <0.001 | 5.572 (2.779–11.175) | <0.001 | |
| Histologic grade | ||||||
| G1 | 55 | Reference | ||||
| G2 | 178 | 1.162 (0.686–1.969) | 0.576 | |||
| G3 | 123 | 1.185 (0.683–2.057) | 0.545 | |||
| G4 | 12 | 1.681 (0.621–4.549) | 0.307 | |||
| Adjacent hepatic tissue inflammation | ||||||
| None | 118 | Reference | ||||
| Mild | 101 | 1.204 (0.723–2.007) | 0.476 | |||
| Severe | 17 | 1.144 (0.447–2.930) | 0.779 | |||
| AFP(ng/ml) | ||||||
| ≤400 | 215 | Reference | ||||
| >400 | 64 | 1.075 (0.658–1.759) | 0.772 | |||
| Vascular invasion | ||||||
| No | 208 | Reference | ||||
| Yes | 109 | 1.344 (0.887–2.035) | 0.163 | |||
| Child-Pugh grade | ||||||
| A | 218 | Reference | ||||
| B&C | 22 | 1.643 (0.811–3.330) | 0.168 | |||
| Fibrosis ishak score | ||||||
| 0 | 75 | Reference | ||||
| 1/2 | 31 | 0.935 (0.437–2.002) | 0.864 | |||
| 3/4 | 28 | 0.698 (0.288–1.695) | 0.428 | |||
| 5/6 | 80 | 0.737 (0.410–1.325) | 0.308 | |||
| Residual tumor | ||||||
| R0 | 326 | Reference | ||||
| R1&R2 | 18 | 1.604 (0.812–3.169) | 0.174 | |||