FIG. 4.

Localization of the core p742 promoter. Reporter constructs containing 5′ or 3′ deletions of the E6/E7 region were transfected into CIN-612 9E cells and cultured under (a) monolayer or (b) methylcellulose conditions. Numbers to the left and right of the bars in the schematic diagram represent the nucleotide positions of the 5′ and 3′ termini of the fragments in the HPV31 genome. The raw luciferase values were normalized to the value of fragment H within each experiment, and then the normalized values were averaged. Bars represent ± 1 standard error of the mean.