TABLE 2.
Mouse neuroinvasive phenotypes of selected wild-type strains of YFV following intraperitoneal inoculation into litters of 8-day-old mice
| Sequence | Strain | Source | Passage historya | Log10 TCID50 | LD50 (log10 TCID50) | Avg survival time (days) |
|---|---|---|---|---|---|---|
| South American genotype I | ||||||
| Brazil55B | BeAR 162 | Haemagogus janthinomys | SM4, C6/36#1 | 4.8 | 0.1 | 9.2 |
| Brazil60 | BeAN 23536 | Monkey | SM1, C6/36#1 | 6.8 | 5.5 | 1 |
| Brazil68C | BeAR 142658 | Haemagogus sp. | ?, C6/36#1 | 6.8 | 5.5 | 8.8 |
| Brazil73B | BeAN 232869 | Mosquito | Mosq 1, SM2 | 2.2 | 0.9 | 10.2 |
| Venezuela61 | PHO 424 | Human | C6/36#2, SM2 | 6.4 | 0.9 | 9 |
| South American genotype I-XL | ||||||
| Brazil73A | BeAN 233164 | Haemagogus | Mosq 4 | 4.2 | 3.7 | 10.4 |
| Panama74B | Jimenez | Human | Mk1 | 5.3 | 0.9 | 10.2 |
| Brazil73D | BeH 233393 | Human | SM1 c6/36#1 | 4.8 | 2.6 | 12 |
| Brazil91C | BeAN 510268 | Alouatta | SM1 c6/36#1 | 4.5 | 3.8 | 11 |
| Brazil92A | BeAR 512943 | Haemagogus | C6/36#1 | 5.0 | 3.9 | 10.4 |
| Brazil92B | BeAR 513008 | Sabethes | SM1, C6/36#1 | 4.5 | 4.3 | 6 |
| Brazil92D | BeAR 513060 | Haemagogus | SM1, C6/36#1 | 4.0 | 1.7 | 10.2 |
| Brazil92E | BeAR 513292 | Sabethes | SM1, C6/36#1 | 6.8 | 5.3 | 9.1 |
| Brazil94A | BeAN 527785 | Sabethes | SM1, C6/36#1 | 5.0 | 4.1 | 9.5 |
| Trinidad89A | CAREC 890692 | Sabethes | (NH) C6/36#1 | 4.4 | 2.8 | 10.7 |
| South American genotype II | ||||||
| Bolivia99A | OBS 7687 (JR 035) | Human | C6/36#2 | 5.6 | 1.9 | 9.3 |
| Peru77A | 1362/77 | Human | C6/36#2 | 4.6 | 2.7 | 9.3 |
| Peru78 | 287/78 | Human | SM1: Mosq 2 | 4.8 | 1.8 | 8.5 |
| Peru81A | B4.1 | Human | plaque pick | 5.8 | 2.8 | 9.1 |
| Peru95a | ARV 0544 | Human | SM1, Vero1, C6/36#1 | 3.8 | 1.2 | 10.8 |
| Peru95C | 153 (HEB4236) | Human | C6/36#1 | 7.3 | 1.9 | 8.4 |
| Peru95J | HEB 4245 | Human | SM1, C6/36#1 | 5.8 | 5.3 | 10.8 |
a
Passage history of seed strain in collection. SM, suckling mouse; Mosq, mosquito; Mk, monkey; ham, hamster.