TABLE 3.

Univariable association between determinants at Day 1 (T1) and having frailty at Day 6 (T2).

Determinants at T1	Frail at T2	Non‐Frail at T2	Odds ratio	95% CI
Sex			1.0	0.35–2.92
Female	7 (41.2)	32 (41)
Male	10 (58.8)	46 (59)
Age, years	6.4 (4, 9)	5.3 (4.25, 8.85)	1.0	0.9–1.14
Weight, SDS	−0.34 (−0.83, 0.32)	0.43 (−0.31, 1.24)	0.54	0.33–0.89
Body mass index, SDS	−1.41 (−1.78, −0.8)	−0.74 (1.53, 0.07)	0.53	0.27–1.03
Type of ALL			N.a.
Pre B‐cell	14 (82.3)	71 (91)
T‐cell	2 (11.8)	7 (9)
BPDCN	1 (5.9)	0 (0)
Maintenance week, number	25 (16, 31)	37 (25.5, 46)	0.94	0.9–0.98
Appendicular skeletal muscle mass, SDS	−1.39 (−1.84, −0.87)	−0.54 (−1.28, −0.02)	0.49	0.28–0.83
Dominant handgrip strength, SDS	−0.73 (−1.65, 0.2)	0 (−0.6, 0.88)	0.41	0.22–0.77
Fatigue (PedsQL‐MFS), SDS	−0.46 (−1.31, 0.38)	−0.49 (−2.1, 0.56)	1.0	0.98–1.03
Timed Up and Go test, SDS	0.26 (−0.52, 0.68)	−0.54 (−1.28, −0.02)	2.02 b	1.2–3.39
Physical activity, minutes per day a	44 (23, 62)	90 (45, 147)	0.98	0.96–0.99

Note: Values are depicted as median (interquartile range) or number (%), Bold indicates statistical significance.

Abbreviations: BPDCN, blastic plasmacytoid dendritic cell neoplasm, n.a., not applicable.

^a Analyzed in subcohort of children 3–11 years of whom physical activity minutes per day were available (n = 72).

^b Higher SDS = slower performance increases the risk of frailty.