TABLE 4.
Algorithms for describing resistance to LPV-RTVa
| Algorithm (reference no.) | Data set size | Mutations in HIV protease |
|---|---|---|
| Lopinavir mutation score (22) | 112 | L10F, L10I, L10R, L10V, K20M, K20R, L24I, M46I, M46L, F53L, I54L, I54T, I54V, L63P, A71I, A71L, A71V, A71T, V82A, V82F, V82T, I84V, L90M |
| ATU mutation set (17) | 792 | Amino acid positions 10, 20, 24, 33, 36, 47, 48, 54, 82, 84 |
| Parkin et al. (31) | 1,941 | L10F, L10I, L10R, L10V, G16E, K20M, K20R, L24I, V32I, L33F, E34Q, K43T, M46I, M46L, I47A, I47V, G48M, G48V, I50V, I54A, I54L, I54M, I54S, I54T, I54V, Q58E, L63P, L63T, A71I, A71L, A71V, A71T, G73T, T74S, V82A, V82F, V82S, V82T, I84V, L89I, L89M, L90M |
| Wang et al. (40) | 1,322 | L10I, Q18Y, L24I, V32I, L33F, L33M, K43T, K45T, M46I, M46L, G48V, F53L, I54A, I54S, I54V, K55R, Q58E, A71V, I72V, G73S, G73T, T74S, V82A, I84V, I85V, L90M, C95F, C95L |
a
Mutations listed in bold italics emerged in at least 1 of 19 subjects upon viral rebound. ATU, Authorisation Temporaire d’Utilisation.