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. 2005 Mar;79(6):3675–3683. doi: 10.1128/JVI.79.6.3675-3683.2005

FIG. 2.

FIG. 2.

Aging and CMV infection lead to an imbalance in the cytokine production profile of the total unpurified CD8+ T-cell population. The production of IL-2, IL-4, and IFN-γ in response to stimulation with PMA-ionomycin was studied. (A) Cytokine production profile of the total gated CD8+ T-cell population in CMV antibody (Ab)-negative and -positive persons of different age groups. Statistical comparisons between the groups were done, and the results are presented as means ± SEM. Significant differences are shown as follows: *, CMV Ab- versus CMV Ab+ persons within each age group; †, young versus elderly; #, middle-aged versus elderly within persons of one CMV Ab status. (B) The example of two young, two middle-aged, and two elderly persons is shown, one without and one with latent CMV infection in each age group. CD8 cells producing either IL-2, IL-4, or IFN-γ were gated and analyzed for their expression of CD45RA and CD28.