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The size of the 69-insert correlates with the level of ZDV resistance
| Size of insert (no. of amino acids) | No. of sequences | Mean fold resistance to indicated drug
|
Mean RCa (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ABC | ddI | 3TC | d4T | TFV | ddC | ZDV | |||
| 1 | 28 | 7.3 | 2.3 | 89 | 4.4 | 3.4 | 2.3 | 333 | 50 |
| 2 | 104 | 24 | 4.1 | 100 | 14 | 10 | 4.7 | 1,222 | 34 |
| 5 | 1 | 19 | 3.2 | 12 | 6.5 | 13 | 3.1 | >2,000 | 21 |
| 8 | 1 | 7.1 | 2.3 | 8.8 | 5.1 | 5.1 | 2.4 | >2,000 | 83 |
Mean RC compared to wild-type control.
