A proposed model of managing SCD in the older adult. (A) The traditional single disease focused framework of comorbidity where comorbid conditions are considered as disease pairs, such as SCD and diabetes mellitus, SCD and cardiovascular disease, and SCD and dementia. Most clinical practice guidelines are based on this framework. (B) Multimorbid conceptual framework demonstrating a more patient-centric approach to managing the older adult with SCD in the context of multiple chronic conditions, geriatric syndromes, functional status, and social determinants of health. CKD, chronic kidney disease; CNS, central nervous system; CVD, cardiovascular disease; DM, diabetes mellitus.