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. 2005 Mar;79(6):3748–3757. doi: 10.1128/JVI.79.6.3748-3757.2005

FIG. 6.

FIG. 6.

T-cell immunity to induced SHIV and HCV. Multiple infusions of SHIV- or HCV-peptide-pulsed whole blood were administered to chronically SHIVmn229-infected macaques. (A) Increased SIV Gag, Pol, HIV-1 Env, and HIV-1 Tat-Rev-Vpu-SIV-Nef-specific CD4+ (•)- and CD8+ (□)-T-cell responses by ICS following three monthly infusions of SHIV peptide-pulsed whole blood (arrows) in a macaque with partial control of SHIVmn229 viremia. (B) Correlation between baseline plasma SHIV viral load (prior to infusion) and induction of total SHIV-specific CD4+-T-cell responses following SHIV-peptide-pulsed whole-blood infusion in five macaques previously infected with SHIVmn229. (C) Induction of CD4+ (•)- and CD8+ (□)-T-cell responses to both structural and nonstructural HCV proteins following three monthly infusions of HCV-peptide-pulsed whole blood (arrows) in a macaque with controlled SHIVmn229 viremia.