TABLE 1.
IVK of Gag- and Pol-pulsed cells after SHIV challenge and correlation with IFN-γ ELISPOT and ICS
| Macaque | % IVKa |
Spot-forming cells/106 PBMC by IFN-γ ELISPOT |
IFN-γ ICS |
|||||
|---|---|---|---|---|---|---|---|---|
| Gag | Pol | Gag | Pol | Gag | Pol | Gag | Pol | |
| E20b | 3.8 | 5.7 | 8 | 0 | 0.0 | 0.0 | 0.0 | 0.0 |
| E22b | 91.3 | 31.9 | 73 | 13 | 1.7 | 1.6 | 3.3 | 0.2 |
| B00c | 64.8 | 22.6 | 73 | 0 | 3.3 | 0.4 | 0.4 | 0.2 |
| H8c | 85.0 | 12.7 | 593 | 8 | 13.7 | 0.2 | 27.0 | 0.2 |
| H20c | 92.3 | 99.8 | 230 | 20 | 3.4 | 2.1 | 5.2 | 3.0 |
| H21c | 98.3 | 99.2 | 183 | 65 | 4.7 | 4.3 | 8.8 | 5.0 |
a
IVK experiments were performed 2 weeks after SHIVmn229 challenge. IFN-γ ELISPOT and ICS data were from 2 and 3 weeks postchallenge, respectively.
b
Macaques were not vaccinated with DNA and FPV but previously studied for IVK.
c
Macaques previously vaccinated with DNA and FPV and studied for IVK.