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Male rats exposed to 4-52 via polymeric implants containing 0 (sham), 1, 5, or 10% of 4-52 for 28 days showed a significant decrease in liver weight as a percentage of their body weight, but no other organ weights were affected. Ad.gland: adrenal gland, BAT: brown adipose tissue. Data are expressed as mean ± standard deviation (n=15). ** p < 0.001. Statistical differences were compared by one-way analysis of variance (ANOVA) with Fisher’s LSD test for multiple comparisons.
